Now available as a multimedia e-dition, the new 5th Edition of Wall and Melzack's Textbook of Pain, has been completely updated under new editorial leadership, together with a host of international contributors.

This established masterwork provides the most complete coverage of pain currently available. Which means that in one single resource you can now access the latest clinical research, knowledge and practical expertise concerning the neurophysiology, psychology, and assessment of every type of pain syndrome seen in practice.

Wall & Melzack's presents a complete and contemporary portfolio of pharmacologic, surgical, electrostimulative, physiotherapeutic, and psychological management options. In addition, the e-dition offers you access to a dedicated website that is continuously updated for the life of the edition. Giving you a comprehensive resource that continues to evolve as medical developments occur. In this website all drug information is linked to Mosby's Drug Consult, all references are linked to PubMed, and all illustrations and tables can be downloaded into PowerPoint^® slides for presentations.

• Covers all aspects of the physiology, psychology, assessment, and management of pain.
• Features contributions from a "who's who" of authorities in pain medicine, ensuring that the book is the most current, reliable, and complete core reference in the field.

Section 1. Neurobiology of pain
1. Peripheral mechanisms of cutaneous nociception

2. Cellular and molecular properties of primary afferent neurons

3. Inflammatory mediators and modulators of pain

4. Neuroanatomical substrates of spinal nociception
5. Plasticity and pain: role of the dorsal horn

6. Representation of pain in the brain
7. Central nervous system mechanisms of pain modulation
8. Development of pain pathways and mechanisms
9. The genetics of pain
10. Animal models of pain
11. Ascending projection systems
12. Autonomic-endocrine-immune interactions in acute and chronic pain
13. Itch

Section 2. Assessment and psychology of pain
14. Emotions and psychobiology
15. Cognitive and learning aspects
16. Psychiatric disorders and pain
17. Studies of pain in human subjects
18. Pain assessment in adult patients
19. Measurement and assessment of paediatric pain

20. Assessment of pain beliefs, coping, and function
21. Hypnotic analgesia
22. The cognitive-behavioural approach to pain management
23. Pain, opiates and addiction
24. Placebo analgesia

Section 3. Pharmacology and Treatment of Pain
25. Central pharmacology of nociceptive transmission
26. Methods of therapeutic trials
27. Opiates: basic mechanisms
28. Opioids: clinical use
29. Antipyretic analgesics: basic aspects
30. NSAIDs and Coxibs: clinical use
31. Antidepressant analgesics: a systematic review and comparative study
32. Anticonvulsant medications in neuropathic pain
33. Local anaesthetic blocks and epidurals
34. Cannabinoids
35. Analgesic drugs in development
36. Supratentorial neurosurgery for the treatment of pain
37. Spinal cord and brain stimulation
38. Transcutaneous electrical nerve stimulation and acupuncture
39. Peripheral and central nervous system surgery for pain
40. Physiotherapy and pain

Section 4. Clinical states: Deep somatic tissue
41. Basic mechanisms of deep somatic pain
42. Postoperative pain and its management
43. Osteoarthritis and rheumatoid arthritis
44. Myofascial pain and fibromyalgia syndrome
45. Surgical treatment for back and neck pain
46. Low back pain
47. Repetitive strain injury

Section 5. Viscera
48. Visceral pain: basic mechanisms
49. Thorax
50. A clinical perspective on abdominal pain
51. Genitourinary pain
52. Obstetric pain

Section 6. Clinical States: Headache and facial pain
53. Acute and chronic dental and orofacial pain
54. Headache
55. Primary neurovasuclar headache
56. Tension-type headache
57. Pain in and around the eye

Section 7. Clinical states: Neuropathic pain
58. Response of nerves to injury in relation to neuropathic pain
59. Mechanisms of experimental neuropathic pain: integration from animal models
60. Central consequences of peripheral nerve damage
61. Phantom limb
62. Painful peripheral neuropathies
63. Trigeminal and glossopharyngeal neuralgia
64. Complex regional pain syndromes
65. Root disorders and arachnoiditis
66. Pain following spinal cord injury
67. Central pain
68. Pharmacological therapy for neuropathic pain

Section 8. Clinical states: Cancer pain
69. Cancer pain: causes, consequences and therapeutic opportunities
70. The assessment of cancer pain
71. Analgesic therapy and palliative care in children
72. Cancer pain: treatment overview
73. Pain control in the care of the dying

Section 9. Clinical States: Special cases
74. Pain in the elderly
75. Sex and gender differences in pain and its relief
76. Epidemiology of pain

Index

By Stephen McMahon, PhD, Sherrington Professor of Physiology, Director, Centre for Neuroscience Research, King's College London, UK; and Martin Koltzenburg, MD, Hononary Consultant, National Hospital for Neurology and Neurosurgery, Professor of Pain Research, Institute of Child Health/Institute of Neurology, University College London, UK