This revised 8th Edition continues to provide comprehensive, exhaustive, and authoritative coverage of nephrology-both underlying basic science and pathophysiology, and clinical diagnosis management of renal diseases and conditions. Fourteen new chapters, two new sections, and an online component keep you absolutely current.

• Coverage of the complete breadth of the specialty broadens your knowledge base.
• A discussion on the basic science that underpins clinical nephrology prepares you for certification or recertification.
• A comprehensive selection of the most important sources in nephrology expands your reference needs.
• More than 550 full-color high-quality photographs, as well as abundant and carefully chosen figures, algorithms, and tables add to your comprehension of the material.
• A visually aided, logical organization gives you access to the information you need quickly.
• The fully-searchable entire contents of the book · regular updates · an image library for electronic presentations · links to related resources · relevant material from other nephrology texts · and more are all accessible online, giving you anytime, anywhere access to the latest information.

I. Normal Renal Function: Molecular, Cellular, Structural, and Physiologic Principles

1. Embryology and Maturation - Susan Quaggin

2. Anatomy and Topography - Kirsten Madsen

3. Cell Biology - Pierre Ronco/Gerard Friedlander

4. Hemodynamics - Lance D. Dworkin

5. Metabolic Basis of Solute Transport - Bruce C. Kone

6. Transport of Inorganic Solutes - David B. Mount

7. Transport of Organic Solutes - Orson Moe

8. Renal Acidification - Lee L. Hamm

9. Cell Biology of Vasopressin Action - Dennis Brown

10. Urine Concentration and Dilution - Mark A. Knepper

II. Integrated Control of Body Fluid Volume and Composition

11. Vasoactive Peptides and the Kidney - Mark E. Cooper/Karin Jandeleit-Dahm

12. Arachidonate Metabolites - Raymond C. Harris

13. Extracellular Fluid and Edema Formation - Karl L. Skorecki

14. Disorders of Water Balance - Tomas Berl

15. Disorders of Acid-Base Balance - Thomas D. DuBose

16. Disorders of Potassium Balance - David B. Mount

17. Disorders of Calcium, Magnesium, and Phosphate Balance - Kevin Martin

III. Epidemiology and Risk Factors in Kidney Disease

18. Epidemiology of Kidney Disease - Josef Coresh

19. Risk Factors and Kidney Disease - A. Levey/ V. Menon/M. Sarnak

20. Nephron Endowment - Valerie Luyckx/Barry Brenner

21. Gender and Kidney Disease - Joel Neugarten

22. Aging and Kidney Disease - Moshe Levi

IV. Evaluation of the Patient with Kidney Disease

23. Approach to the Patient with Kidney Disease - Robert Toto

24. Laboratory Assessment of Kidney Disease - Bertram L. Kaiske

25. Interpretation of Urine Electrolyte and Acid-Base Parameters - Mitchell Halperin

26. Adaptation to Nephron Loss - Maarten Taal/Barry Brenner

27. Renal and Systemic Manifestations of Glomerular Disease - Sharon Anderson

28. Diagnostic Kidney Imaging - William D. Boswell

29. Interventional Nephrology - David Warnock

V. Disorders of Kidney Function

30. Acute Renal Failure - Michael Clarkson

31. Primary Glomerular Disease - Ronald Falk

32. Secondary Glomerular Disease - Gerald Appel

33. Micro and Macrovascular Diseases of the Kidney - Kamal F. Badr

34. Tubulointerstitial Diseases - Giuseppe Remuzzi/Marc E. de Broe/Noberto Perico

35. Urinary Tract Infection, Pylonephritis, and Reflux Nephropathy - Nina E. Tolkoff-Rubin/ Robert Rubin

36. Urinary Tract Obstruction - Mark L. Zeidel

37. Diabetic Nephropathy - Hans-Henrik Parving

38. Nephrolithiasis - David Bushinsky

39. Renal Neoplasia - Michael Atkins

VI. Genetic Basis of Kidney Disease

40. Inherited Disorders of Podocyte Function - Martin Pollak

41. Inherited Disorders of the Renal Tubule - Daniel G. Bichet

42. Cystic Diseases of the Kidney - Jared J. Grantham

VII. Hypertension and the Kidney

43. Primary and Secondary Hypertension - Jon D. Blumenfeld

44. Renovascular Hypertension and Ischemic Nephropathy - Stephen C. Textor

45. Hypertension and Kidney Disease in Pregnancy - Ravi Thadani

46. Antihypertensive Drugs - Matthew R. Weir

47. Diuretics - Christopher S. Wilcox

VIII. The Consequences of Renal Failure

48. Pathophysiology of Uremia - Timothy W. Meyer

49. Cardiovascular Apsects of Kidney Disease - Patrick Parfrey

50. Hematologic Aspects of Kidney Disease - Steven Fishbane

51. Endocrine Aspects of Kidney Disease - Ajay K. Singh

52. Neurologic Aspects of Kidney Disease - Allen Arief

53. Renal Osteodystrophies - Sharon Moe

IX. Conservative and Pharmacologic Management of Kidney Disease

54. Diet and Kidney Disease - Gary Curham /Glenn Chertow

55. Specific Pharmacologic Approaches to Renoprotection - Dick DeZeeuw

56. Erythropoietin Therapy in Renal Disease and Renal Failure - John C. Stivelman

57. Vitamin D, Calcimimetics, and Phosphate Binders - William Goodman

58. Prescribing Drugs in Kidney Disease - George R. Aronoff

X. Invasive Therapy of Renal Failure

59. Hemodialysis - Gerald Schulman

60. Peritoneal Dialysis - Peter Blake

61. Intensive Care Nephrology - Bruce Molitoris

62. Plasmapheresis - Bradley M. Denker

63. Extracorporeal Treatment of Poisoning - Ingrid Chang

XI. Renal Transplantation

64. Immunobiology - Mohamed Sayegh

65. Donor and Recipient Issues - Bertram Kaiske

66. Clinical Management - Colm C. Magee

XII. Frontiers in Nephrology

67. Attaining Immunologic Tolerance - Mohamed Sayegh

68. Xenotransplantation - David Sachs

69. Tissue Engineering and Regeneration - Marc Hammerman

70. Stem Cells in Renal Biology and Medicine - Karl L. Skorecki

71. Genomics and Protemics in Nephrology - Joseph V. Bonventre

By Barry M. Brenner, MD, AM(Hon), DSc(Hon), DMSc(Hon), FRCP(Lond, Hon), Samuel A. Levine Professor of Medicine, Harvard Medical School, Director, Renal Division; and Senior Physician, Department of Medicine, Brigham and Women's Hospital, Boston, MA