Highly Commended, RSM Awards 2007


Highly Commended, Basic and Clinical Sciences, BMA Awards 2007


In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.

• Covers the entire range of diagnostic/investigative techniques, providing you with all of the necessary tools to formulate an accurate diagnosis.
• Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis.
• Addresses the "knowledge explosion" over the last 10 years in the fields of molecular genetics and immunocytochemistry, including all of the latest clinically relevant investigative techniques.
• Focuses on diagnostic techniques and on the diagnostic interpretation of results, giving you a portable reference book and a bench book in a single volume.

Section 1 The Biopsy: Normal and Diseased Muscle
1. The procedure of muscle biopsy
2. Histological and histochemical stains and reactions
3. Normal muscle
4. Definition of pathological changes seen in muscle biopsies
5. Ultrastructural changes in diseased muscle
6. Immunohistochemistry
7. How to read a biopsy

Section 2 Pathological Muscle: Individual Diseases
8. Classification of neuromuscular disorders
9. Neurogenic disorders
10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy
11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies
12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies
13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy
14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy
15. Congenital myopathies
16. Myofibrillar myopathies
17. Metabolic myopathies I: glycogenoses
18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies
19. Endocrine disorders
20. Ion channel disorders
21. Myasthenic syndromes
22. Inflammatory myopathies
23. Toxic and drug-induced myopathies
Russell Lane, Charing Cross Hospital

Appendix 1. Glossary of commonly used terms

References

Index

By Victor Dubowitz, BSc, MD, PhD, FRCP, DCH, Professor of Paediatrics, Department of Paediatrics and Neonatal Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK; and Caroline A. Sewry, BSc, PhD, FRCPath, Professor of Muscle Pathology, Dubowitz Neuromuscular Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK; Centre for Inherited Neuromuscular Disorders, Department of Histopathology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK