The only reference of its kind in the field ! The new edition of this definitive resource examines the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. It describes the presentation, differential diagnosis, course, management, and prognosis of every major condition. Drs. Cassidy and Petty have meticulously revised their masterwork to integrate important new scientific advances and clinical developments.

• Features exhaustive reviews of the major clinical syndromes, describing the complex web of symptoms, signs, and lab abnormalities characteristic of these disorders in order to make diagnosis and treatment easier.
• Grounds treatment protocols in the best scientific evidence available today.
• Establishes an internationally accepted nosography of classification criteria based on the ACR, EULAR, and ILAR criteria.
• Clarifies complex concepts and demonstrates key techniques with 400 illustrations, which include new figures and a new four-color insert.
• Integrates the knowledge and experience of the founding fathers of pediatric rheumatology as well as a who's who of international experts in the field.

BASIC CONCEPTS 1

C H A P T E R 1 Introduction to the Study of Rheumatic

C H A P T E R 2
Structure and Function

C H A P T E R 3
The Immune System and the Inflammatory
Response

C H A P T E R 4
Integrative Genomics

C H A P T E R 5
Pharmacology and Drug Therapy

C H A P T E R 6
Design, Measurement and Analysis of Clinical
Investigations

C H A P T E R 7
Assessment of Health Status, Function and
Quality of Life Outcomes: Methodology and
Instruments

C H A P T E R 8
A General Approach to Management of Rheumatic Disease in Children

C H A P T E R 9
Chronic Arthritis in Childhood

C H A P T E R 1 0
Polyarthritis

C H A P T E R 1 1
Oligoarthritis

C H A P T E R 1 2
Systemic Arthritis

C H A P T E R 1 3
Juvenile Ankylosing Spondylitis

C H A P T E R 1 4
Psoriatic Arthritis

C H A P T E R 1 5
Arthropathies of Inflammatory Bowel
Disease

C H A P T E R 1 6
Systemic Lupus Erythematosus

C H A P T E R 1 7
Neonatal Lupus Erythematosus

C H A P T E R 1 8
Juvenile Dermatomyositis

C H A P T E R 1 9
The Systemic Sclerodermas and Related
Disorders

C H A P T E R 2 0
Localized Sclerodermas

C H A P T E R 2 1
Overlap Syndromes

C H A P T E R 2 2
Vasculitis and its Classification

C H A P T E R 2 3
Leukocytoclastic Vasculitis

C H A P T E R 2 4
Polyarteritis Nodosa and Related

C H A P T E R 2 5
Kawasaki Disease

C H A P T E R 2 6
Granulomatous Vasculitis, Giant Cell Arteritis
and Sarcoidosis

C H A P T E R 2 7
Behcet's Disease

C H A P T E R 2 8 Infectious Arthritis and Osteomyelitis

C H A P T E R 2 9 Lyme Disease

C H A P T E R 3 0 Reactive Arthritis
Ruben Burgos-Vargas and Janitzia Vazquez-Mellado

C H A P T E R 3 1
Acute Rheumatic Fever and Post-streptocococcal

C H A P T E R 3 2
Musculoskeletal Manifestations of Systemic
Disease

C H A P T E R 3 3
Immunodeficiencies and the Rheumatic
Diseases

C H A P T E R 3 4
Periodic Fever Syndromes in Children

C H A P T E R 3 5
Cryopyrin associated Periodic Syndrome

C H A P T E R 3 6
Noninflammatory Musculoskeletal Pain
Conditions

C H A P T E R 3 7
Pain and the Pain Amplification Syndromes


C H A P T E R 3 8
Skeletal Maturation and Bone Mineralization in
the Pediatric Rheumatic Diseases


C H A P T E R 3 9
Skeletal Malignancies and Related Disorders


C H A P T E R 4 0
Primary Disorders of Bone and Connective
Tissues

By James T. Cassidy, MD, Professor of Child Health; Chief, Division of Pediatric Rheumatology, Department of Child Health, University of Missouri Health Sciences Center and Children's Hospital, Columbia, MO; and Ross E. Petty, MD, PhD, FRCPC, Professor of Pediatrics, University of British Columbia; Head, Division of Rheumatology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada