Description
For most people today, ABO-incompatible kidney transplantation still carries the image of pronounced hyperacute rejection. However, with modern immunosuppressive therapy, hyperacute rejection will not occur within the first 24 hours. Clinical statistics in Japan show 3 cases of hyperacute rejection, but all of these occurred because the recipient was mistakenly transfused during surgery with frozen plasma of the same blood type. Delayed hyperacute rejection, occurring after the first 24 hours, is most likely to develop within 1 week post transplant. It does not manifest suddenly, but several years after transplantation. This means that humoral rejection ceases to occur after accommodation has been established. The use of evidence-based medicine to correct misconceptions in this area has proven to be meaningful.
The publication of these data has made it possible to break down fixed thinking and prejudices previously regarded as fact in relation to ABO-incompatible kidney transplantation. It is believed that this will prove to be a major contribution in the future development of immunology. As these data are provided as a common resource for physicians performing transplantation procedures, it has encouraged more widespread implementation of organ transplantation.
Reviews
"Professor Takahashi published his first book, "ABO-Incompatible Kidney Transplantation", in 2001 and this excellent sequel updates not only his own experience, but that of all Japanese units carrying out ABO-incompatible renal transplants. (...) This is a very interesting book based on a wealth of experience and should be of value to all transplants clinicians and tissue-typing laboratories." - Transplantation, Volume 81, Number 7, April 15, 2006
Contents
Author Information
Edited by K. Takahashi, Niigata University, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Science, Japan
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